The use of natural compounds in neutrophil immunomodulation: a narrative review
DOI:
https://doi.org/10.36560/19620262283Palavras-chave:
Biological Products, Polymorphonuclear Cells, InflammationResumo
Autoimmune diseases have shown significant global growth and already affect millions of people, directly contributing to the loss of quality of life of affected patients, being characterized by the recruitment and activation of neutrophils (NE), whose characteristic cellular effector mechanisms culminate in tissue damage and chronicity of the condition. This qualitative narrative review was conducted to synthesize evidence on natural compounds with immunomodulatory potential on NE, with emphasis on mechanisms of action relevant to the treatment and understanding of autoimmune pathogenesis. The identified studies demonstrate that several natural compounds identified in the review reduce neutrophilic activation through mechanisms such as inhibition of chemotaxis, suppression of ROS, blockade of Ca²⁺ influx, modulation of NF-κB, reduction of pro-inflammatory cytokines, and inhibition of NET formation. It is concluded that natural compounds represent promising adjuvant strategies for the control of neutrophilic inflammation, potentially contributing to safer and more effective therapeutic approaches. Future clinical application depends on further experimental studies and clinical trials confirming efficacy, safety, and ideal dosage.
Referências
ANDRADE, Micássio Fernandes et al. The 3-phenylcoumarin derivative 6,7-dihydroxy-3-[3′,4′-methylenedioxyphenyl]-coumarin downmodulates the FcγR- and CR-mediated oxidative metabolism and elastase release in human neutrophils: possible mechanisms underlying inhibition of the formation and release of neutrophil extracellular traps. Free Radical Biology and Medicine, v. 115, p. 1-11, 2018. DOI: 10.1016/j.freeradbiomed.2017.12.012.
ANDRADE, Pedro Henrique de Almeida et al. Doenças autoimunes: atualização no diagnóstico e tratamento em clínica geral. Brazilian Journal of Implantology and Health Sciences, v. 6, n. 10, p. 1999-2009, 2024. DOI: 10.36557/2674-8169.2024v6n10p1999-2009.
ANTONIO, Gisele Damian et al. Fitoterapia na atenção primária à saúde. Revista de Saúde Pública, v. 48, n. 3, p. 541-553, 2014. DOI: 10.1590/S0034-8910.2014048004901.
BOBOWSKA, Aneta et al. Comparative studies of urolithins and their phase II metabolites on macrophage and neutrophil functions. European Journal of Nutrition, v. 60, n. 4, p. 1957-1972, 2021. DOI: 10.1007/s00394-020-02386-y.
CHEN, Hanze et al. (+)-Borneol inhibits the generation of reactive oxygen species and neutrophil extracellular traps induced by phorbol-12-myristate-13-acetate. Frontiers in Pharmacology, v. 13, p. 1023450, 2022. DOI: 10.3389/fphar.2022.1023450.
COLE, Justin et al. COlchicine to Prevent PeriprocEdural Myocardial Injury in Percutaneous Coronary Intervention (COPE-PCI): coronary microvascular physiology pilot substudy. Journal of Interventional Cardiology, v. 2022, p. 1098429, 2022. DOI: 10.1155/2022/1098429.
DAI, Si-Yang et al. Honokiol and magnolol: a review of structure-activity relationships of their derivatives. Phytochemistry, v. 223, p. 114132, 2024. DOI: 10.1016/j.phytochem.2024.114132.
DEL RIO, Daniele et al. Dietary (poly)phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases. Antioxidants & Redox Signaling, v. 18, n. 14, p. 1818-1892, 2013. DOI: 10.1089/ars.2012.4581.
HERRERO-CERVERA, Andrea et al. Neutrophils in chronic inflammatory diseases. Cellular & Molecular Immunology, v. 19, n. 2, p. 177-191, 2022. DOI: 10.1038/s41423-021-00832-3.
KISHIMOTO, Atsuhiro et al. Newly developed highly bioavailable curcumin formulation, curcuRouge™, reduces neutrophil/lymphocyte ratio in the elderly: a double-blind, placebo-controlled clinical trial. Journal of Nutritional Science and Vitaminology, v. 67, n. 4, p. 249-252, 2021. DOI: 10.3177/jnsv.67.249.
LEE, Tzong-Huei et al. New coumarins and anti-inflammatory constituents from the fruits of Cnidium monnieri. International Journal of Molecular Sciences, v. 15, n. 6, p. 9566-9578, 2014. DOI: 10.3390/ijms15069566.
LI, Yi-Min et al. Cnidium monnieri: a review of traditional uses, phytochemical and ethnopharmacological properties. The American Journal of Chinese Medicine, v. 43, n. 5, p. 835-877, 2015. DOI: 10.1142/S0192415X15500500.
MINAIYAN, Mohsen et al. Effects of Tamarindus indica fruit and seed extracts on experimental ulcerative colitis in rats. Research in Pharmaceutical Sciences, v. 19, n. 3, p. 276-286, 2024.
NARUKO, Takahiko et al. Neutrophil infiltration of culprit lesions in acute coronary syndromes. Circulation, v. 106, n. 23, p. 2894-2900, 2002. DOI: 10.1161/01.cir.0000042674.89762.20.
OHINATA, Hitomi et al. Suppressive effect of resveratrol, catechin and their conformationally constrained analogs on neutrophil extracellular trap formation by HL-60-derived neutrophils. Journal of Clinical Biochemistry and Nutrition, v. 75, n. 1, p. 17-23, 2024. DOI: 10.3164/jcbn.23-80.
PAULA, Fabiana S. et al. Modulation of human neutrophil oxidative metabolism and degranulation by extract of Tamarindus indica L. fruit pulp. Food and Chemical Toxicology, v. 47, n. 1, p. 163-170, 2009. DOI: 10.1016/j.fct.2008.10.023.
PHAN, Hong Thi Lam et al. Polypharmacological effects of honokiol on allergic rhinitis: modulation of TMEM16A, TRPV1, and calcium signaling. Biomedicine & Pharmacotherapy, v. 191, p. 118460, 2025. DOI: 10.1016/j.biopha.2025.118460.
RAJ, Vishnu et al. Nerolidol mitigates colonic inflammation: an experimental study using both in vivo and in vitro models. Nutrients, v. 12, n. 7, p. 2032, 2020. DOI: 10.3390/nu12072032.
RIDKER, Paul M. et al. Antiinflammatory therapy with canakinumab for atherosclerotic disease. New England Journal of Medicine, v. 377, n. 12, p. 1119-1131, 2017. DOI: 10.1056/NEJMoa1707914.
SANTA-CECÍLIA, Flávia V. et al. Anti-inflammatory and antinociceptive effects of Garcinia brasiliensis. Journal of Ethnopharmacology, v. 133, n. 2, p. 467-473, 2011. DOI: 10.1016/j.jep.2010.09.036.
SCHEPETKIN, Igor A. et al. Chemical composition and immunomodulatory activity of Hypericum perforatum essential oils. Biomolecules, v. 10, n. 6, p. 916, 2020. DOI: 10.3390/biom10060916.
SCHEPETKIN, Igor A. et al. Neutrophil immunomodulatory activity of nerolidol, a major component of essential oils from Populus balsamifera buds and propolis. Plants, v. 11, n. 23, p. 3399, 2022. DOI: 10.3390/plants11233399.
SCHEPETKIN, Igor A. et al. Neutrophil immunomodulatory activity of (−)-borneol, a major component of essential oils extracted from Grindelia squarrosa. Molecules, v. 27, n. 15, p. 4897, 2022. DOI: 10.3390/molecules27154897.
SCHEPETKIN, Igor A. et al. Neutrophil immunomodulatory activity of natural organosulfur compounds. Molecules, v. 24, n. 9, p. 1809, 2019. DOI: 10.3390/molecules24091809.
TALMOR, Nina et al. Neutrophil activation and adhesiveness in coronary artery disease: results from the COLCHICINE-PCI biomarker substudy. Journal of the American Heart Association, v. 13, n. 19, p. e036701, 2024. DOI: 10.1161/JAHA.124.036701.
WIGERBLAD, Gustaf; KAPLAN, Mariana J. Neutrophil extracellular traps in systemic autoimmune and autoinflammatory diseases. Nature Reviews Immunology, v. 23, n. 5, p. 274–288, 18 out. 2022.
YANG, Hui et al. Curcumin attenuates lupus nephritis by inhibiting neutrophil migration via PI3K/AKT/NF-κB signalling pathway. Lupus Science & Medicine, v. 11, n. 2, p. e001220, 2024. DOI: 10.1136/lupus-2024-001220.
YANG, Shun-Chin et al. Luteolin attenuates neutrophilic oxidative stress and inflammatory arthritis by inhibiting Raf1 activity. Biochemical Pharmacology, v. 154, p. 384-396, 2018. DOI: 10.1016/j.bcp.2018.06.003.
ZHANG, Zhuoxian et al. Epigallocatechin-3-gallate inhibits the formation of neutrophil extracellular traps and suppresses the migration and invasion of colon cancer cells by regulating STAT3/CXCL8 pathway. Molecular and Cellular Biochemistry, v. 478, n. 4, p. 1-12, 2023. DOI: 10.1007/s11010-022-04550-w.
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