Frailty, sarcopenia and associated factors in elderly people with diabetes mellitus: an integrative review
DOI:
https://doi.org/10.36560/18320252070Keywords:
aging, frailty, sarcopenia, diabetes mellitus, chronic diseaseAbstract
Aging is a natural, dynamic, gradual, and irreversible process in the development of the individual, involving psychological, biological, and social factors. According to estimates by the IBGE, people over 65 years of age will account for more than a quarter of Brazilians in 2060. In addition, age-related chronic noncommunicable diseases (NCDs) are expected to increase, which will have a greater impact on people's disability and dependence. This study analyzed the knowledge produced in the scientific literature on the identification of factors related to frailty and sarcopenia in elderly individuals with diabetes mellitus in the period 2013-2023. The results point to the importance of multidimensional approaches that combine lifestyle changes, physical exercise programs, nutritional interventions, and strict diabetes control. The practice of resistance activities, combined with protein supplementation and the use of drugs when necessary, has shown promise in mitigating sarcopenia. Addressing frailty and sarcopenia in older adults with T2DM requires careful monitoring by healthcare professionals and managers to ensure that preventive and therapeutic strategies are implemented effectively. Early identification and appropriate management of these conditions can significantly contribute to promoting health, maintaining autonomy, and improving the quality of life of older adults.
References
BENTO, A. Como fazer uma revisão da literatura: considerações teóricas e práticas. Revista JA (Associação Académica da Universidade da Madeira), n. 65, p. 42-44, 2012. Disponível em: http://www3.uma.pt/bento/Repositorio/Revisaodaliteratura.pdf.
Bourdel-Marchasson, G. C. et. al. Frailty and Brain-Muscle Correlates in Older People With Type 2 Diabetes: A structural-MRI Explorative Study. J Nutr Health Aging. 2019-07-01; 23(7): 637-640 DOI: 10.1007/s12603-019-1229-3. Disponível em: https://www.bordeaux-neurocampus.fr/article/frailty-and-brain-muscle-correlates-in-older-people-with-type-2-diabetes-a-structural-mri-explorative-study/
Calvani R, et. al. Identification of a Circulating Amino Acid Signature in Frail Older Persons with Type 2 Diabetes Mellitus: Results from the Metabofrail Study. Nutrients. 2020 Jan 12;12(1):199. doi: 10.3390/nu12010199. PMID: 31940925; PMCID: PMC7019630. Disponível em: https://pmc.ncbi.nlm.nih.gov/articles/PMC7019630/
Cesari, M. et al. The geriatric management of frailty as paradigm of "The end of the disease era". European Journal of Internal Medicine, v. 42, p. 64-70, 2017. Disponível em: https://www.ejinme.com/article/S0953-6205(17)30196-2/fulltext.
Çakmak, G. et al. The role of obesity in sarcopenia and frailty in the elderly. Journal of Aging Research, v. 2021, p. 1-9, 2021. Disponível em: https://doi.org/10.1155/2021/6543217.
Critical Appraisal Skills Programme. CASP Qualitative Research Checklist. 2018. Disponível em: https://casp-uk.net/casp-tools-checklists/. Acesso em: 5 mar. 2025.
Comerciante, R. A. et al. Relationship of Fat Mass Index and Fat Free Mass Index With Body Mass Index and Association With Function, Cognition and Sarcopenia in Pre-Frail Older Adults. Frontiers in Endocrinology. Disponível em: https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2021.765415/full
Dent, E. et al. International Clinical Practice Guidelines for Sarcopenia (ICFSR): Screening, Diagnosis and Management. Journal of Nutrition, Health & Aging, v. 23, p. 770-789, 2019. Disponível em: https://doi.org/10.1007/s12603-019-1215-9
Fernandes, D. S. et al. Instrumentos utilizados na avaliação da capacidade funcional, fragilidade e sarcopenia em idosos: revisão integrativa. Cogit. Enferm. 28, 2023. Disponível em: https://doi.org/10.1590/ce.v28i0.89719
Fried, L. P. et al. Frailty in older adults: evidence for a phenotype. Journal of Gerontology: Medical Sciences, v. 56, n. 3, p. 146-156, 2001. Disponível em: https://pubmed.ncbi.nlm.nih.gov/11253156/.
Instituto Brasileiro de Geografia e Estatística (IBGE). Projeções da população: revisão – 2018. Rio de Janeiro: IBGE, 2018.
Izquierdo, M. et al. Multicomponent physical exercise program: The path toward healthy aging and longevity. Journal of Aging Research, v. 2021, p. 1-12, 2021. Disponível em: https://doi.org/10.1155/2021/7325983.
Izzo, A. et al. Uma revisão narrativa sobre a sarcopenia no diabetes mellitus tipo 2: prevalência e fatores associados. Nutrientes, v. 13, n. 183, p. 1-18, 2021. Disponível em: https://www.mdpi.com/2072-6643/13/1/183.
Law M, Stewart D, Pollock N, Lets lienL, Bosch J, Westmorland M. Guidelines for critical review form - quantitative studies. Adapted Word Version –
Hamilton. [Internet]. Ontario: McMaster University Occupational Evidence-based Practice Research Group; 1998. Disponível em: https://alterbiblio.com/content/uploads/2021/09/mcmasters_quantitative-review.pdf
Liccini, A. P. et al. To investigate rates of frailty and sarcopenia and 6-month health outcomes in a clinical sample of patients with diabetes mellitus. The Journal of Post-acute and Long-term Care Medicine. Volume 17 , Edição 9 p846-851 01 de setembro de 2016. Disponível em: https://www.jamda.com/article/S1525-8610(16)30254-7/abstract
Lien, A. S.; Hwand, J. S.; Jiang, Y. D. Diabetes related fatigue, sarcopenia and frailty. Journal of Diabetes Investigation, v. 9, n. 1, p. 3-4, 2018. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754541/.
Lin C. H, et al. Proteomics Analysis to Identify and Characterize the Biomarkers and Physical Activities of Non-Frail and Frail Older Adults. Int J Med Sci. 2017 Feb 23;14(3):231-239. doi: 10.7150/ijms.17627. PMID: 28367083; PMCID: PMC5370285. Disponível em: https://pubmed.ncbi.nlm.nih.gov/28367083/
Lu, Y. et al. Psychological factors associated with frailty in older adults. Geriatrics & Gerontology International, v. 20, n. 7, p. 678-685, 2020. Disponível em: https://doi.org/10.1111/ggi.13994.
Lu Y, et. al. Lower insulin level is associated with sarcopenia in community-dwelling frail and non-frail older adults. Front Med (Lausanne). 2022 Nov 22;9:971622. doi: 10.3389/fmed.2022.971622. PMID: 36482911; PMCID: PMC9722960. Disponível em: https://pubmed.ncbi.nlm.nih.gov/36482911/
Luo, Y. et al. Sarcopenic obesity and adverse outcomes in older adults: A systematic review. Journal of Clinical Medicine, v. 12, n. 3, p. 395, 2023. Disponível em: https://doi.org/10.3390/jcm12030395.
Marques, M. V.; Santos, S. S. A. N.; Lima, M. V.; et al. Distribuição espacial da mortalidade por diabetes no Brasil. Revista Saúde e Desenvolvimento Humano, v. 8, n. 3, 2020. Disponível em: http://revistas.unilasalle.edu.br/index.php/saude_desenvolvimento.
Malmstrom, T. K.; morley, J. E. SARC-F: A simple questionnaire to rapidly diagnose sarcopenia. Journal of the American Medical Directors Association, v. 14, n. 8, p. 531-532, 2013. Disponível em: https://doi.org/10.1016/j.jamda.2013.02.018.
Merchant RA, Soong JTY, Morley JE. Gender Differences in Body Composition in Pre-Frail Older Adults With Diabetes Mellitus. Front Endocrinol (Lausanne). 2022 Feb 15;13:795594. doi: 10.3389/fendo.2022.795594. PMID: 35242108; PMCID: PMC8885520. Disponível em: https://pubmed.ncbi.nlm.nih.gov/35242108/
Morley, J. E. Frailty consensus: a call to action. Journal of the American Medical Directors Association, v. 14, n. 6, p. 392-397, 2013.
Ouzzani, M. et al. Rayyan - um aplicativo da web e móvel para revisões sistemáticas. Systematic Reviews, v. 4, n. 210, p. 1-10, 2016. Disponível em: https://systematicreviewsjournal.biomedcentral.com/articles/10.1186/s13643-016-0384-4.
Page, M. J. et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ, v. 372, n. 71, 2021. Disponível em: https://doi.org/10.1136/bmj.n71.
Perna S, et al. Performance of Edmonton Frail Scale on frailty assessment: its association with multi-dimensional geriatric conditions assessed with specific screening tools. BMC Geriatr. 2017 Jan 4;17(1):2. doi: 10.1186/s12877-016-0382-3. PMID: 28049443; PMCID: PMC5209899. Disponível em: https://pubmed.ncbi.nlm.nih.gov/28049443/
Ribeiro, I. A. et al. Frailty syndrome in the elderly in elderly with chronic diseases in Primary Care. Rev Esc Enferm USP · 2019;53:e03449. DOI: http://dx.doi.org/10.1590/S1980-220X2018002603449
Tamura Y, et al. Prevalence of frailty, cognitive impairment, and sarcopenia in outpatients with cardiometabolic disease in a frailty clinic. BMC Geriatr. 2018 Nov 6;18(1):264. doi: 10.1186/s12877-018-0955-4. PMID: 30400831; PMCID: PMC6219198. Disponível em: https://pubmed.ncbi.nlm.nih.gov/30400831/
Whittemore R, Knafl K. The integrative review: updated methodology. J Adv Nurs. 2005 Dec;52(5):546-53. Doi: 10.1111/j.1365-2648.2005.03621.x.
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