Preliminary evaluation of the interaction with Albumin/DNA and in vitro evaluation of the antioxidant properties promoted by thiosemicarbazones and thiazole compounds

Pedro Henrique do Bomfim  Nascimento; Keriolaine Lima dos  Santos; Arthur Van Lauter Albuquerque  Pereira; Júlia Conceição Bezerra dos  Santos; Diego Santa Clara Marques; Iranildo José da  Cruz Filho; Maria do Carmo Alves de  Lima

doi:10.36560/17320241919

Autores

Pedro Henrique do Bomfim Nascimento Federal University of Pernambuco
Keriolaine Lima dos Santos Federal University of Pernambuco
Arthur Van Lauter Albuquerque Pereira Federal University of Pernambuco
Júlia Conceição Bezerra dos Santos Federal University of Pernambuco
Diego Santa Clara Marques Federal University of Pernambuco
Iranildo José da Cruz Filho Federal University of Pernambuco
Maria do Carmo Alves de Lima Federal University of Pernambuco

DOI:

https://doi.org/10.36560/17320241919

Palavras-chave:

antioxidante, macromoléculas, potencial biológico

Resumo

Tiosemicarbazonas e tiazóis são conhecidos por suas diversas atividades biológicas. Este estudo introduziu duas séries de moléculas, 4-(3-(4-nitrofenil)-4-feniltiazol-2(3H)-ilideno)-hidrazina)-metil)-fenol e 4-(3-(4-clorofenil)- 4-feniltiazol-2(3H)-ilideno)-hidrazina)-metil)-fenol, que apresentam potencial biológico como agentes antioxidantes. O estudo também avaliou a interação desses compostos com diversas macromoléculas de HSA/DNA. Os resultados da atividade antioxidante mostraram que os tiazóis no ensaio DPPH exibiram valores de IC50 variando de 439,4 a 691,67 µM. No ensaio ABTS, as tiosemicarbazonas exibiram atividade significativa, variando de 39,19 a 50,03 µM. Os ensaios de interação foram realizados com albumina sérica humana (HSA) e DNA. Todos os compostos foram capazes de interagir tanto com DNA (interação baixa a moderada) quanto com HSA (interação moderada a alta).

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