Preliminary evaluation of the interaction with Albumin/DNA and in vitro evaluation of the antioxidant properties promoted by thiosemicarbazones and thiazole compounds

Authors

  • Pedro Henrique do Bomfim Nascimento Federal University of Pernambuco
  • Keriolaine Lima dos Santos Federal University of Pernambuco
  • Arthur Van Lauter Albuquerque Pereira Federal University of Pernambuco
  • Júlia Conceição Bezerra dos Santos Federal University of Pernambuco
  • Diego Santa Clara Marques Federal University of Pernambuco
  • Iranildo José da Cruz Filho Federal University of Pernambuco
  • Maria do Carmo Alves de Lima Federal University of Pernambuco

DOI:

https://doi.org/10.36560/17320241919

Keywords:

antioxidant, macromolecules, biological potential

Abstract

Thiosemicarbazones and thiazoles are known for their diverse biological activities. This study introduced two series of molecules, 4-(3-(4-nitrophenyl)-4-phenylthiazol-2(3H)-ylidene)-hydrazine)-methyl)-phenol and 4-(3-(4-chlorophenyl)-4-phenylthiazol-2(3H)-ylidene)-hydrazine)-methyl)-phenol, which exhibit biological potential as antioxidant agents. The study also assessed the interaction of these compounds with various HSA/DNA macromolecules. The results of the antioxidant activity showed that thiazoles in the DPPH assay exhibited IC50 values ranging from 439.4 to 691.67 µM. In the ABTS assay, thiosemicarbazones exhibited significant activity, ranging from 39.19 to 50.03 µM. Interaction assays were carried out with human serum albumin (HSA) and DNA. All compounds were able to interact with both DNA (low to moderate interaction) and HSA (moderate to high interaction).

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Published

2024-04-30

How to Cite

Nascimento, P. H. do B. ., Santos, K. L. dos ., Pereira, . A. V. L. A. ., Santos, J. C. B. dos ., Santa Clara Marques, D., Cruz Filho, I. J. da ., & Lima, M. do C. A. de . (2024). Preliminary evaluation of the interaction with Albumin/DNA and in vitro evaluation of the antioxidant properties promoted by thiosemicarbazones and thiazole compounds. Scientific Electronic Archives, 17(3). https://doi.org/10.36560/17320241919

Issue

Vol. 17 No. 3 (2024): Scientific Electronic Archives (mai / jun)

Section

Health Science

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